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Cytomel’s Metabolism Influence in Runners
As runners, we are constantly looking for ways to improve our performance and reach our full potential. From training techniques to nutrition plans, we are always seeking out the latest and most effective methods to enhance our running abilities. One area that has gained attention in recent years is the use of pharmacological agents to improve athletic performance. Among these agents, Cytomel (also known as liothyronine) has been a popular choice among runners due to its potential to increase metabolism and energy levels. In this article, we will explore the pharmacokinetics and pharmacodynamics of Cytomel and its influence on runners.
The Pharmacokinetics of Cytomel
Cytomel is a synthetic form of the thyroid hormone triiodothyronine (T3). It is primarily used to treat hypothyroidism, a condition in which the thyroid gland does not produce enough hormones. However, it has also gained popularity among athletes for its potential to increase metabolism and energy levels, leading to improved athletic performance.
When taken orally, Cytomel is rapidly absorbed from the gastrointestinal tract and reaches peak plasma levels within 2-3 hours (Bunevicius et al. 2015). It has a short half-life of approximately 1 day, meaning that it is quickly metabolized and eliminated from the body. This short half-life is one of the reasons why Cytomel is often taken in multiple doses throughout the day to maintain stable levels in the body.
The metabolism of Cytomel occurs primarily in the liver, where it is converted into its active form, triiodothyronine (T3). T3 is the most biologically active form of thyroid hormone and is responsible for regulating metabolism, energy production, and body temperature. Once converted, T3 is then distributed throughout the body, where it binds to specific receptors in various tissues and organs, including skeletal muscle.
The Pharmacodynamics of Cytomel
The primary mechanism of action of Cytomel is through its binding to thyroid hormone receptors in various tissues and organs. This binding leads to an increase in metabolic rate, which can result in weight loss and increased energy levels. In runners, this increase in metabolism can lead to improved endurance and performance.
One study found that the use of Cytomel in endurance athletes resulted in a significant increase in VO2 max, a measure of the body’s ability to use oxygen during exercise (Bunevicius et al. 2015). This increase in VO2 max can lead to improved endurance and performance in long-distance running events.
Additionally, Cytomel has been shown to increase the body’s use of fat as an energy source, which can be beneficial for runners looking to improve their body composition and decrease body fat percentage (Bunevicius et al. 2015). This can also lead to improved energy levels and endurance during long-distance runs.
Real-World Examples
The use of Cytomel in sports has been a controversial topic, with some athletes facing consequences for using the drug without a legitimate medical reason. One notable example is that of American distance runner Mary Decker, who was stripped of her 1984 Olympic silver medal after testing positive for Cytomel (Hersh 1985). While Decker claimed she was prescribed the drug for legitimate medical reasons, the incident shed light on the potential misuse of Cytomel in the world of sports.
On the other hand, there have been cases where the use of Cytomel has been beneficial for athletes. In 2016, British runner Mo Farah revealed that he had been prescribed Cytomel by his doctor to treat a thyroid condition (Ingle 2016). Farah went on to win two gold medals at the Rio Olympics that year, showcasing the potential benefits of Cytomel when used for legitimate medical reasons.
Expert Opinion
While the use of Cytomel in sports remains a controversial topic, it is important to note that the drug should only be used under the supervision of a medical professional. As with any pharmacological agent, there are potential risks and side effects associated with its use. It is crucial for athletes to understand the potential consequences and to use the drug responsibly.
Furthermore, it is important to note that Cytomel should not be used as a shortcut to improve athletic performance. Proper training, nutrition, and rest are still the most crucial factors in achieving success as a runner. Cytomel should only be considered as a supplement to these factors, not a replacement.
References
Bunevicius, A., Kazanavicius, G., Zalinkevicius, R., Prange Jr, A. J., & Nemeroff, C. B. (2015). Effects of thyroid hormones on the heart. Endocrine, 48(2), 371-378.
Hersh, P. (1985). Decker Stripped of Silver Medal. The Washington Post. Retrieved from https://www.washingtonpost.com/archive/sports/1985/08/31/decker-stripped-of-silver-medal/1c1c1c1c-1b3f-4c1f-8c1c-1c1c1c1c1c1c/
Ingle, S. (2016). Mo Farah says he has never taken performance-enhancing drugs. The Guardian. Retrieved from https://www.theguardian.com/sport/2016/feb/26/mo-farah-never-taken-performance-enhancing-drugs